Heavy rain early Thursday buffeted Florida's Kennedy Space Center where Discovery had already been rolled out to the launchpad after early glitches that postponed the launch three times earlier in the week were resolved.

"There is a no go for 24 hours because of the weather," a spokesman at Kennedy Space Center said.

Launch is now set for 3:04 pm (1904 GMT) Friday, with weather forecasts showing a 60-percent chance of favorable conditions, the US space agency said.

"From a vehicle prospective we are ready to go," said mission management team leader Mike Moses.

Although the weather has been favorable since Monday, rain rolled in just as the other glitches were solved, pushing back the launch, originally set for Monday, a fourth time.

"It's a lack of luck," said Kennedy Space Center spokesman Allard Beutel. "It did not rain for weeks here, that's unusual."

If Friday's launch gets pushed back yet again, Sunday's launch window has only a 40 percent chance of favorable conditions.

The next launch window for the mission would come on December 1 and last only a few days.

Discovery's 11-day mission was originally scheduled for November 1. Its all-American six-member crew, including female mission specialist Nicole Stott, will deliver a pressurized logistics module called Leonardo, which will be permanently attached to the space station to provide more storage space.

The shuttle will also bring Robonaut 2, the first human-like robot in space and a permanent addition to the orbiting space station, as well as spare parts.

Two space walks, for maintenance work and component installation, are scheduled.

The flight to the ISS is the fourth and final shuttle flight of the year, and the last scheduled for Discovery, the oldest in the three-shuttle fleet that is being retired in 2011.

"Discovery is not going out easy," said shuttle launch director Mike Leinbach. "She is giving us a little bit of trouble but that is fine, she will fly perfectly when she does."

The three US shuttles -- the other two are Atlantis and Endeavour -- are due to be shipped off to museums after a final shuttle mission to the space station in late February.

That means Russian Soyuz spacecraft, a modernized version of which recently dropped off three fresh crew members to the ISS, doubling the crew to six, will for several years be the only vehicle for transporting humans into space.

However, NASA's recently approved 2011 budget has left the door open to an additional shuttle flight in June.

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